Journal: Cancer Microenvironment

Article Title: Mammographic Density and Matrix Metalloproteinases in Breast Tissue

doi: 10.1007/s12307-009-0031-x

Figure Lengend Snippet: Proportion of subjects with positive stains for MMPs and TIMP3 by ethnicity

Article Snippet: Following TMA construction, 5 μm sections of TMA blocks were sent to Wake Forest University for immunohistochemical staining with the following markers: MMP1 (1906-1), MMP3 (1908-1), MMP9 (1939-1), MMP12 (1906-1; all Epitomics, Inc., Burlingame, CA), and TIMP3 (CA 0577; Cell Applications, Inc., San Diego, CA).

Techniques:

Journal: Cancer Microenvironment

Article Title: Mammographic Density and Matrix Metalloproteinases in Breast Tissue

doi: 10.1007/s12307-009-0031-x

Figure Lengend Snippet: Percent density for MMP1, MMP12, and TIMP3 by tissue type and ethnicity (Adjusted for age at mammogram, BMI, ethnicity, parity, age at first live birth, age at menarche, menopausal status, hormone use at mammogram, family history of breast cancer, and tumor stage)

Article Snippet: Following TMA construction, 5 μm sections of TMA blocks were sent to Wake Forest University for immunohistochemical staining with the following markers: MMP1 (1906-1), MMP3 (1908-1), MMP9 (1939-1), MMP12 (1906-1; all Epitomics, Inc., Burlingame, CA), and TIMP3 (CA 0577; Cell Applications, Inc., San Diego, CA).

Techniques:

Journal: Diagnostic Pathology

Article Title: Promoter methylation and expression of TIMP3 gene in gastric cancer

doi: 10.1186/1746-1596-8-110

Figure Lengend Snippet: Gastric carcinoma TIMP3 promoter methylation and protein expression

Article Snippet: TIMP3 antibody and SP kit were purchased from Boster Biological Engineering Co., Ltd. (Dalian).

Techniques: Methylation, Expressing

Journal: Diagnostic Pathology

Article Title: Promoter methylation and expression of TIMP3 gene in gastric cancer

doi: 10.1186/1746-1596-8-110

Figure Lengend Snippet: TIMP3 protein immunohistochemisty (SP 400×): a, normal gastric tissue; b, early gastric cancer; c, advanced gastric cancer; d, transfer of lymph node.

Article Snippet: TIMP3 antibody and SP kit were purchased from Boster Biological Engineering Co., Ltd. (Dalian).

Techniques:

Journal: Diagnostic Pathology

Article Title: Promoter methylation and expression of TIMP3 gene in gastric cancer

doi: 10.1186/1746-1596-8-110

Figure Lengend Snippet: Relationship between advanced gastric cancer pathology TIMP3 methylation and its protein expression level

Article Snippet: TIMP3 antibody and SP kit were purchased from Boster Biological Engineering Co., Ltd. (Dalian).

Techniques: Methylation, Expressing

Journal: Ecotoxicology and environmental safety

Article Title: Endosulfan promotes cell proliferation and extracellular matrix accumulation through TGF-β/Smad signaling pathway in HRMCs.

doi: 10.1016/j.ecoenv.2021.113040

Figure Lengend Snippet: Fig. 2. Dose-effects of endosulfan on ECM accumulation related genes in HRMCs. HRMCs were exposed to different concentrations of endosulfan or D control for 48 h. Relative mRNA expression levels of MMP2 (A) and TIMP3 (B) were measured by qRT-PCR. Representative Western blots was shown (C) and protein expression levels of LN, TIMP3 and MMP3 were densitometrically quantified (D). *P < 0.05, **P < 0.01 vs D.

Article Snippet: Primary antibodies include MMP3 (Cat. AF513, R&D Systems, Shanghai, China), LN (Cat. sc-13144, Santa Cruz), Smad2/3 (Cat. E1A6362, Cat. E1A6449, EnoGene, Nanjing, China) and p-Smad2/3(p-Ser467/425) (Cat. AM12299, Cat. AM1398 AURAGENE BIOTECH, Hunan, China), Smad7 (Cat. 25840-1-AP, Proteintech, Wuhan, China), TIMP3 (Cat. A00477, BOSTER), IL-8 (Cat. A2541, Abclonal, Wuhan, China), p21 (Cat. A1483, Abclonal, Wuhan, China), p27 (Cat. A0290, Abclonal, Wuhan, China), MMP2 (Cat. A6247, Abclonal, Wuhan, China).

Techniques: Control, Expressing, Quantitative RT-PCR, Western Blot

Journal: Journal of Ovarian Research

Article Title: Suitability assessment of baseline concentration of MMP3, TIMP3, HE4 and CA125 in the serum of patients with ovarian cancer

doi: 10.1186/s13048-017-0373-9

Figure Lengend Snippet: Concentrations of TIMP3, MMP3, HE4 and CA125 in blood serum, depending on the histopathologic diagnosis of patients

Article Snippet: TIMP3 concentrations were quantified in serum by multiplex fluorescent bead-based immunoassays (Luminex Corporation, Austin, TX, USA) using commercial Human TIMP3 Magnetic Bead Panel 2 (Merck Millipore, Billerica, MA, USA).

Techniques: Biomarker Discovery

Journal: Journal of Ovarian Research

Article Title: Suitability assessment of baseline concentration of MMP3, TIMP3, HE4 and CA125 in the serum of patients with ovarian cancer

doi: 10.1186/s13048-017-0373-9

Figure Lengend Snippet: The ROC curve for MMP3, TIMP3, HE4 and CA125 protein in diagnostic patients with ovarian cancer and with benign ovarian cysts without hormonal status division

Article Snippet: TIMP3 concentrations were quantified in serum by multiplex fluorescent bead-based immunoassays (Luminex Corporation, Austin, TX, USA) using commercial Human TIMP3 Magnetic Bead Panel 2 (Merck Millipore, Billerica, MA, USA).

Techniques: Diagnostic Assay

Journal: Journal of Ovarian Research

Article Title: Suitability assessment of baseline concentration of MMP3, TIMP3, HE4 and CA125 in the serum of patients with ovarian cancer

doi: 10.1186/s13048-017-0373-9

Figure Lengend Snippet: The ROC curve for MMP3, TIMP3, HE4 and CA125 protein in diagnostic patients with ovarian cancer and with benign ovarian cysts for postmenopausal women

Article Snippet: TIMP3 concentrations were quantified in serum by multiplex fluorescent bead-based immunoassays (Luminex Corporation, Austin, TX, USA) using commercial Human TIMP3 Magnetic Bead Panel 2 (Merck Millipore, Billerica, MA, USA).

Techniques: Diagnostic Assay

Journal: Journal of Ovarian Research

Article Title: Suitability assessment of baseline concentration of MMP3, TIMP3, HE4 and CA125 in the serum of patients with ovarian cancer

doi: 10.1186/s13048-017-0373-9

Figure Lengend Snippet: Individual proteins sensitivity and specificity depending on hormonal status

Article Snippet: TIMP3 concentrations were quantified in serum by multiplex fluorescent bead-based immunoassays (Luminex Corporation, Austin, TX, USA) using commercial Human TIMP3 Magnetic Bead Panel 2 (Merck Millipore, Billerica, MA, USA).

Techniques:

Journal: Journal of Ovarian Research

Article Title: Suitability assessment of baseline concentration of MMP3, TIMP3, HE4 and CA125 in the serum of patients with ovarian cancer

doi: 10.1186/s13048-017-0373-9

Figure Lengend Snippet: Cox regression analyses of progression free survival and overall survival of classic prognostic factor, MMP3 and TIMP3

Article Snippet: TIMP3 concentrations were quantified in serum by multiplex fluorescent bead-based immunoassays (Luminex Corporation, Austin, TX, USA) using commercial Human TIMP3 Magnetic Bead Panel 2 (Merck Millipore, Billerica, MA, USA).

Techniques:

Journal: Journal of Ovarian Research

Article Title: Suitability assessment of baseline concentration of MMP3, TIMP3, HE4 and CA125 in the serum of patients with ovarian cancer

doi: 10.1186/s13048-017-0373-9

Figure Lengend Snippet: Individual proteins concentration levels in patients with ovarian cancer, depending on the staging and grading

Article Snippet: TIMP3 concentrations were quantified in serum by multiplex fluorescent bead-based immunoassays (Luminex Corporation, Austin, TX, USA) using commercial Human TIMP3 Magnetic Bead Panel 2 (Merck Millipore, Billerica, MA, USA).

Techniques: Concentration Assay

Journal: Journal of Ovarian Research

Article Title: Suitability assessment of baseline concentration of MMP3, TIMP3, HE4 and CA125 in the serum of patients with ovarian cancer

doi: 10.1186/s13048-017-0373-9

Figure Lengend Snippet: Overall survival stratified by MMP3 and TIMP3 in examined patient with ovarian cancer

Article Snippet: TIMP3 concentrations were quantified in serum by multiplex fluorescent bead-based immunoassays (Luminex Corporation, Austin, TX, USA) using commercial Human TIMP3 Magnetic Bead Panel 2 (Merck Millipore, Billerica, MA, USA).

Techniques: